বৃহস্পতিবার, ৩১ মে, ২০১২

Despite loss, Israeli chess grandmaster wins fans

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Finally An Automotive Repair Shop for Women! | The large free ...

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Is EU short on options to end violence in Syria?

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বুধবার, ৩০ মে, ২০১২

Why chemotherapy fails

Why chemotherapy fails [ Back to EurekAlert! ] Public release date: 29-May-2012
[ | E-mail | Share Share ]

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science

Research led by Weizmann Institute scientists show why leukemia often returns

The fight against cancer is not won in a single battle: Long after a cancer has been beaten into remission, it can return. The reason for this is under debate, and much is unclear. New research led by Weizmann Institute scientists shows that, at least for one type of blood cancer, the source of cancer recurrence is in a set of cells that do not proliferate as quickly as regular cancer cells, and thus able to survive chemotherapy. The findings, which appeared today in the journal Blood, have some important implications for the future of the war on cancer.

Cancer involves a breakdown in the mechanism that regulates the pace of cell division. When this happens, cells divide rapidly, leading to unchecked growth that overruns the body. The most common chemotherapy drugs are those which specifically attack cells that are undergoing rapid division, and these, indeed, often destroy all the cancer and cure the patient.

But there are also quite a few leukemia patients who go through chemotherapy only to have the cancer return. Why does this happen? Several explanations have been proposed. One is that the chemotherapy does not kill every last cancer cell, leaving a few to continue dividing out of control until the disease returns in full force. A second explanation proposes that chemotherapy does get all the regular cancer cells, but there is another type of cancer cell that hides in the body. As opposed to the rapidly dividing majority of cancer cells, these undergo slow division, enabling them to evade the chemotherapy drugs. These insidious cells can give rise to new rapidly-dividing cancer cells, which is why they are known as "cancer stem cells."

Which explanation is correct? The debate is an important one because, if the first explanation holds true, improving upon the existing treatments might help, while the second implies that a completely different approach to treatment will be needed to root out the slowly dividing cancer stem cells.

To attempt to resolve that debate, the team of Prof. Ehud Shapiro of the Weizmann Institute's Biological Chemistry, and Applied Mathematics and Computer Sciences Departments, worked with scientists and physicians from Rambam Medical Center and the Technion, both in Haifa. They used a method of reconstructing cell lineage trees that has been developed over the past few years in Shapiro's lab. This method is based on the fact that the genetic material in different body cells accumulates unique mutations during cell division, and these mutations are passed on to daughter cells during cell division. By comparing mutations, one can map out cells' detailed family trees, and thus determine how far back they share a common ancestor. The end product of this analysis is a tree that reconstructs the genealogy of the cells from their earliest forebears at the base of the tree to the youngest cells at the tips of the branches.

To reconstruct the cancer cell lineage tree, the team used two sets of blood samples: the first taken from leukemia patients right after the disease was diagnosed, and the second from those patients who had undergone chemotherapy and in whom the cancer had returned. The researchers could then trace the relationships of the recurring cancer cells back to see if they descended from the original cancer cells. The lineage tree showed that, at least in some of the patients, the source of the renewed cancer was not in the rapidly proliferating cancer cells, but rather in cells that were close to the root of the tree. These cells had only divided a few times. In other words, the cancer arose from cells that divide very slowly, making them resistant to the attacks of chemotherapy drugs.

Shapiro: "We know that in many cases, chemotherapy alone is not able to cure leukemia. Our results suggest that to completely eliminate it, we must look for a treatment that will not only eliminate the rapidly dividing cells, but also target the cancer stem cells that are resistant to conventional treatment."

###

Participating in the research were Dr. Liran Shlush of the Technion's Rappaport Faculty of Medicine and Rambam Medical Center; Noa Chapal-Ilani and Dr. Rivka Adar of the Weizmann Institute; Profs. Karl Skorecki and Jacob Rowe of the Technion; Dr. Tsila Zuckerman of Rambam and the Technion; and additional investigators.

Prof. Ehud Shapiro's research is supported by the Paul Sparr Foundation; Miel de Botton, UK. The Carolito Stiftung; and the European Research Council. Prof. Shapiro is the incumbent of the Harry Weinrebe Professorial Chair of Computer Science and Biology. His research is also supported by an ERC Advanced Grant.

The Weizmann Institute of Science in Rehovot, Israel, is one of the world's top-ranking multidisciplinary research institutions. Noted for its wide-ranging exploration of the natural and exact sciences, the Institute is home to 2,700 scientists, students, technicians and supporting staff. Institute research efforts include the search for new ways of fighting disease and hunger, examining leading questions in mathematics and computer science, probing the physics of matter and the universe, creating novel materials and developing new strategies for protecting the environment.

Weizmann Institute news releases are posted on the World Wide Web at http://wis-wander.weizmann.ac.il/, and are also available at http://www.eurekalert.org/


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Why chemotherapy fails [ Back to EurekAlert! ] Public release date: 29-May-2012
[ | E-mail | Share Share ]

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science

Research led by Weizmann Institute scientists show why leukemia often returns

The fight against cancer is not won in a single battle: Long after a cancer has been beaten into remission, it can return. The reason for this is under debate, and much is unclear. New research led by Weizmann Institute scientists shows that, at least for one type of blood cancer, the source of cancer recurrence is in a set of cells that do not proliferate as quickly as regular cancer cells, and thus able to survive chemotherapy. The findings, which appeared today in the journal Blood, have some important implications for the future of the war on cancer.

Cancer involves a breakdown in the mechanism that regulates the pace of cell division. When this happens, cells divide rapidly, leading to unchecked growth that overruns the body. The most common chemotherapy drugs are those which specifically attack cells that are undergoing rapid division, and these, indeed, often destroy all the cancer and cure the patient.

But there are also quite a few leukemia patients who go through chemotherapy only to have the cancer return. Why does this happen? Several explanations have been proposed. One is that the chemotherapy does not kill every last cancer cell, leaving a few to continue dividing out of control until the disease returns in full force. A second explanation proposes that chemotherapy does get all the regular cancer cells, but there is another type of cancer cell that hides in the body. As opposed to the rapidly dividing majority of cancer cells, these undergo slow division, enabling them to evade the chemotherapy drugs. These insidious cells can give rise to new rapidly-dividing cancer cells, which is why they are known as "cancer stem cells."

Which explanation is correct? The debate is an important one because, if the first explanation holds true, improving upon the existing treatments might help, while the second implies that a completely different approach to treatment will be needed to root out the slowly dividing cancer stem cells.

To attempt to resolve that debate, the team of Prof. Ehud Shapiro of the Weizmann Institute's Biological Chemistry, and Applied Mathematics and Computer Sciences Departments, worked with scientists and physicians from Rambam Medical Center and the Technion, both in Haifa. They used a method of reconstructing cell lineage trees that has been developed over the past few years in Shapiro's lab. This method is based on the fact that the genetic material in different body cells accumulates unique mutations during cell division, and these mutations are passed on to daughter cells during cell division. By comparing mutations, one can map out cells' detailed family trees, and thus determine how far back they share a common ancestor. The end product of this analysis is a tree that reconstructs the genealogy of the cells from their earliest forebears at the base of the tree to the youngest cells at the tips of the branches.

To reconstruct the cancer cell lineage tree, the team used two sets of blood samples: the first taken from leukemia patients right after the disease was diagnosed, and the second from those patients who had undergone chemotherapy and in whom the cancer had returned. The researchers could then trace the relationships of the recurring cancer cells back to see if they descended from the original cancer cells. The lineage tree showed that, at least in some of the patients, the source of the renewed cancer was not in the rapidly proliferating cancer cells, but rather in cells that were close to the root of the tree. These cells had only divided a few times. In other words, the cancer arose from cells that divide very slowly, making them resistant to the attacks of chemotherapy drugs.

Shapiro: "We know that in many cases, chemotherapy alone is not able to cure leukemia. Our results suggest that to completely eliminate it, we must look for a treatment that will not only eliminate the rapidly dividing cells, but also target the cancer stem cells that are resistant to conventional treatment."

###

Participating in the research were Dr. Liran Shlush of the Technion's Rappaport Faculty of Medicine and Rambam Medical Center; Noa Chapal-Ilani and Dr. Rivka Adar of the Weizmann Institute; Profs. Karl Skorecki and Jacob Rowe of the Technion; Dr. Tsila Zuckerman of Rambam and the Technion; and additional investigators.

Prof. Ehud Shapiro's research is supported by the Paul Sparr Foundation; Miel de Botton, UK. The Carolito Stiftung; and the European Research Council. Prof. Shapiro is the incumbent of the Harry Weinrebe Professorial Chair of Computer Science and Biology. His research is also supported by an ERC Advanced Grant.

The Weizmann Institute of Science in Rehovot, Israel, is one of the world's top-ranking multidisciplinary research institutions. Noted for its wide-ranging exploration of the natural and exact sciences, the Institute is home to 2,700 scientists, students, technicians and supporting staff. Institute research efforts include the search for new ways of fighting disease and hunger, examining leading questions in mathematics and computer science, probing the physics of matter and the universe, creating novel materials and developing new strategies for protecting the environment.

Weizmann Institute news releases are posted on the World Wide Web at http://wis-wander.weizmann.ac.il/, and are also available at http://www.eurekalert.org/


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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BlackBerry maker to study options, warns of loss

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Police: Suspected gunman who kills 3, wounds 2 in Seattle shoots himself

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Hollande set for slim parliament win

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Finding Out What Causes Back Pain ? Remedies Revealed ...

Millions of people suffer from back pain; some of the cases are mild and others are severe. Backaches can strike anyone, even if they are fit as a fiddle and in great health. There is chronic back pain that can last for a long time and has to be treated by a medical care provider; then, there are the minor backaches that are just temporary annoyances. If you want to learn three of the reasons people have backaches, please read the rest of this report.

If you sit at a desk or computer, or anywhere, for a long time without moving around, you might be subject to back pain. Simply sitting, in whatever kind of chair or seat, is the culprit here. The chair can be comfortable, or uncomfortable, and that doesn?t seem to make a difference. The pressure seating exerts on your back is a lot more than the pressure when you are up and about. You may have noticed that many people who work in professions that require them to sit a lot ? such as office workers ? experience more instances of back pain. Some people, following the example of author Philip Roth, place their computers on a high surface such as a lectern or counter-top and work there Many companies now offer their employees desks that can be used either standing or sitting. There?s also the fact that your health and well-being will be improved if you spend more time moving around and standing than if you are seated. This has been proven by research. Maybe the thought of working while standing up doesn?t appeal to you. If so, at least get up from time to time and move around a bit. You back will enjoy the change if you just get up, walk around, stretch, and then go back to work. If you have had a spinal fracture, it can lead to back pain and, in reality, is a common reason for back problems. Osteoporosis ? a reduction of your bone mass ? weakens your bones and can lead to spinal fractures. While this can affect both men and women ? especially in their ?golden? years ? it is most common in women. And, as you can well imagine, when bones are less dense they are weaker and, as a result, can break more easily. Any sudden injury, anywhere in your body, can cause a bone to collapse. This is very painful and, if your spine is involved, it can lead to deformation. Medication is often prescribed for the pain, and in some cases surgery is recommended to help hold fractured bones in place. There is evidence that regular exercise and a healthy diet can reduce the severity of osteoporosis and help prevent spinal fractures. The important thing to keep in mind is that your knowledge plus action on what you learn about proactol has great potential. Take action on this because that is the only thing that will help you.

It seems so many people have a sincere desire to do something, but they fall in the trap of just sitting there and wishing. Make a plan that you will take action, and then work from that plan every day until you see the results you want.

It is not hard at all, really, to use this information if you become aware and commit to it. Let?s see what else there is to know about this topic.

While old age is not itself the cause of back pain, people are prone to many conditions that cause back problems as they get older. Osteoporosis, usually happening to women, reduces the strength of the bones and fractures are more apt to happen. Osteoarthritis can cause pain throughout the body, but the spine is particularly vulnerable.

Without proper treatment, bone density will lessen in strength with age and may cause degenerative disc disease. There are also a number of less common ailments that older people are at risk for and which cause back pain. There are preventative measures you can take to lessen the chances of suffering some of these illnesses; like a daily exercise routine, along with the required supplement to keep your bones fit. Suffering from back pain is very distressing. In fact, it can make it extremely difficult to even rise out of bed each day. As they say, ?knowledge is power?, and if you can discover the root of your back pain, you can take the steps to prevent it returning in the future. The first step, of course, is to take care of any medical conditions that could lead, or contribute, to your back pain. If not, simply pay attention to your overall health and fitness, your diet, and any other issues in your life that may lead to back pain. We have strived to give you the most useful ideas as it relates to this important topic.

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Idaho calls 'Five Wives Vodka' offensive to church

Please check the URL for proper spelling and capitalization. If you're having trouble locating a destination on Yahoo!, try visiting the Yahoo! homepage or look through a list of Yahoo!'s online services.

Please try Yahoo Help Central if you need more assistance.

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Tips And Advice For Dealing With Personal Bankruptcy | sinimotor.com

Description

Don?t wait too long to file for bankruptcy. So many people suffer with debts, and sleepless nights for years. They could have filed for bankruptcy, and been in the clear by now. If you are thinking about filing for bankruptcy, time is of the essence. Make the decision so you can move on that much quicker.

Although filing for personal bankruptcy is one solution to debt problems, it is not the only solution.It is not necessarily the best solution. Before filing for bankruptcy, consider attempting to make payment agreements with your creditors. Credit counseling agencies will be able to help you work out such an agreement.

One of the biggest problems that people face when filing personal bankruptcy is they are in too deep before they seek help. They have borrowed against 401 K?s, IRA?s, and sold personal belongings. These things have unintended consequences. These loans are not allowable deductions in the eyes of the court and will not be used in the bankruptcy calculations.

One you realize you are in financial trouble and have decided to file for personal bankruptcy you should move quickly. Waiting to the last minute to file bankruptcy can cause a number of issues. You may face negative repercussions such as wage or bank account garnishment or foreclosure on your home. You can also not leave time enough for a thorough review of your financial situation, which will limit your available options.

Be honest when talking to your attorney. Your attorney is there to help you, and omitting details about your circumstances will not only make his/her job more difficult, but also may prevent you from getting your discharge. Furthermore, if you don?t disclose what you need to in your bankruptcy petition, you could be accused of committing bankruptcy fraud.

You should start selling things around your house and making budget cuts if you have filed for bankruptcy. Now is the time to start saving money and stop being reckless. You can focus on the future and get your finances in order, so that you can have a promising financial future for the rest of your life.

Do not attempt to pay off any of your favorite creditors before you file for bankruptcy. The reason is that all of your assets will be liquidated and each creditor gets their fair share. It is not your job to decide who deserves to be paid back and who does not.

Try not to put off filing for bankruptcy. If you need to file for bankruptcy, don?t procrastinate. Procrastinating may make legal matters more complicated. It may also cause you a great deal of unneeded stress. You need a clear head and a calm mind when preparing to file for bankruptcy. Don?t let stress complicate things.

A good personal bankruptcy tip is to take it all in stride. You have to remind yourself that you aren?t alone by having to file for bankruptcy. Many other people have found themselves in this situation and a lot of them are probably willing to offer you some form of guidance.

As noted earlier, the current economic climate keeps more people in a constant state of struggle, and many of them are turning to bankruptcy. If you decide that this option is the best one for you, hopefully this article has provided you with helpful guidance you can use to face your financial future and make positive changes.

Jacqueline Borgia is an accomplished scholar concerning File Chapter 11 Bankruptcy

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Yoga Siesta for the Spine Yoga Video

Duration: 21 minutes
Level: All Levels
Views: 2464

Give your spine a joyful release as you lightly take the body into all ranges of spinal plane of motions with Kreg Weiss. From twists to bends, ease tension out of key muscle areas that typically prevent the spine from enjoying fluid space.

Tags: Hatha, Yoga, Kreg Weiss, flow, Body, spine, twists, tension, muscle, release, bends, spinal, ease, kreg, fluid, siesta, motions, space

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Lease a Honda CR-V - Best Family Vehicle | Car Reviews,finance ...

Image of A Honda CR-V - Best Family Vehicle

Best Family Vehicle Honda CR-V - Available to Lease

The UK built Honda CR-V has emerged as the ?Most Popular 4?4?? by honestjohn.co.uk.

The Honda CR-V offers immense quality, space, versatility and comfort and is an excellent choice of family vehicle to lease or purchase.

What We Can Expect

The roofline is lower and the styling is sharper with a bolder grille, creating a more dynamic look. The cabin is roomier and refinement will be improved.

The Honda CR-V is now lighter to improve fuel economy and electronically regulates the torque distribution to the rear wheels. An Eco Assist mode is also new. A button is pressed to go into fuel-saving mode.

The seating is comfy. There is also an excellent one pull folding seat. The dashboard layout is tasteful and simple and there is even better storage than before. The Honda CR-V excels at being a family vehicle with its impressive safety scores and utility. In fact, the cabin is one of the most spacious and comfortable in its class, with easy to load cargo area, making it one of the best picks for families.

All in all, the CR-V delivers a competent package and is a very handsome car that lives up to its high standard of build quality.

The CR-V is a practical, attractive and affordable crossover that will meet consumer needs well and is a key seller, worldwide.

The 2012 Honda CR-V?s main goal is to be an excellent family vehicle and test drivers say that?s exactly what it is.

Keep yourself updated with the latest motoring news by liking us on facebook, following us on twitter or connecting with us on LinkedIn.

If you?re looking to purchase or lease a new Honda contact our sales team. Alternatively, visit our website where you will find new and used Honda?s available for sale or on finance.

Thanks for visiting us today.

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Internet Security ? Ideal Internet security ... - Honest Reviews Online

Go through the write-up as well as learn to safeguard your personal computer coming from spyware.

In the following paragraphs you will discover the 5 methods that every pc consumer should apply to prevent internet criminal offense episodes. Today the actual online world is becoming bigger and bigger along with growing variety of organizations and folks utilizing web like a business location. Normally, online thieves goal personal computers with reduced anti-virus internet security and also devote their legal routines.

However, you can find recommendations that ought to be adopted to be able to protected your computer from internet safety attacks:

Back-up Info ? Experienced computer users understand the significance of retaining their info safe and also away from internet security attacks as well as on a regular basis execute back ups. You can support important computer data by using an external data hard drive such is actually Compact disc, memory stick or perhaps hard drive. These devices you employ depends on the info dimensions. The entire idea is actually anything at all happens to much of your info, you can retrieve these through someplace.

File sharing- One more very important thing being avoided is data files together with unknown people. As a result your computer internet security susceptible as the documents form additional people may contain destructive attacks in which without a good anti-virus internet security software can potentially ruin your pc or even take sensitive information. Be sure you switch off as well as disable file-sharing when not needed.

Disconnecting in the Internet- It is extra reduction thus once you internet is not in use just simply disconnect kind world wide web. That reduces the possibility of online criminals passing your internet security.

Revise security patches- Applications occasionally contain bugs that may be an entrance for your pc for any malicious person to address and probably hurt your computer. As a result, it is very important to be able to regularly improve your security patches and improve.

Preserve updated antivirus computer software firewall- Excellent computer virus software and firewall software are important the different parts of the arsenal to increase internet security software that may protect your personal computer from episodes. Ensure that you keep the anti-virus plan as well as firewall software current.

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More Korean Ultra-Nationalism: Dokdo Wine in California / Territorial Dispute Propaganda Ad Appears at Sydney Airport

The Christian Science Monitor reports on yet another episode in the ongoing tale of Korean ultra-nationalists who want the rest of the world to care about the Liancourt Rocks (Takeshima/Dokdo) :

?The latest ploy: a Napa Valley wine produced by Korean-American dentist Ahn Jae-hyun at his Dokdo Winery that uses the island post code as its moniker.

Illustrating the fervor with which such attempts to garner attention for Korea?s sovereign claims over the outcrop, when the wine debuted on the Korean market the local distributor pledged to donate all proceeds to nonprofit groups promoting Korean sovereign claims in other countries.?


Meanwhile, in Australia, Sydney International Airport has suspended a Korean ultra-nationalist ad campaign after receiving a complaint from the local Japanese consulate. The campaign was displaying large images of the Liancourt Rocks declaring them to be Korean territory in the ?East Sea.? To the uninformed, it might look like a normal tourism ad. Airport authorities probably accepted the ad campaign without realizing that it was actually the work of anti-Japanese organizations that are obsessed with territorial disputes.

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Joplin Hospital Honors 2011 Tornado Survivors

Katlyn Wilkins and Andrea Wilkins Morelli work on securing an American flag in a tree as they deal with the destruction caused by a massive tornado that passed through the town killing at least 139 people on May 29, 2011 in Joplin, Missouri. (Joe Raedle/Getty Images)

Written by
Associated Press

JOPLIN, Mo. (AP) - The Joplin, Mo., hospital where hundreds of injured residents sought help after a deadly tornado struck the town one year ago today is honoring its staff, rescue workers and storm survivors at a memorial service.

Freeman Hospital held a sunrise service Tuesday morning on a day marked by a series of public events in Joplin. The tornado killed 161 people and destroyed one-third of the city, making it the nation's deadliest single tornado in six decades.

Freeman is just eight blocks from St. John's Regional Medical Center, which was destroyed by a direct hit from the EF-5 tornado. That hospital is being rebuilt, but Freeman was undamaged.

The ceremony's speakers included Gov. Jay Nixon and 17-year-old tornado survivor Malichi Murdock, who was struck by debris at a local community theater.

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iamamayzing articles: Advertise on the Internet Tips

Internet or online marketing has now become the most popular way to get your business more exposure. Yes, TV and radio media is still feasible however; campaigns using this very able to make a dent in your operating capital. Advertising and marketing via the internet is the most cost-effective solution, especially if you look at long-term success. Let's face it, taking advantage of millions of users logged onto the Internet on a lower budget more attractive to any business then go for the more expensive TV and radio ads. The only problem with advertising on the Internet is that it needs more strategy and analysis if you want to achieve success in the quickest amount of time.

Decide on a budget. You probably know by now that you can actually advertise and execute a comprehensive marketing campaign online for free or at most, with a significantly lower cost. It is true however; is free and inexpensive strategies can only bring you instant success. If you want long-term durability and success, you will definitely need the money to do so. Do not worry; it still should be cheaper than running a TV marketing campaign. It is said, be sure to complete a realistic budget for your online marketing. The budget must consist of the cost to go to a pay per click campaigns on various search engines, graphics and web design costs for the site and banner advertising, and labor costs to spearhead and manage your online marketing efforts.

Create a website and blog. Hire a web designer with superior high-level graphic design skills to create a website for you. Hire a web content writer to create content for your site. When finished, move the person to create and maintain your blog. This blog is useful in the sharing of relevant content to your fan base. This will increase the retention and exposure to indirect marketing approach. Make sure the website and blogs are interlinked with each other to drive traffic from one site to another and vice versa.

Create a pay per click campaigns. Google ads should always be your best bet since Google is the most popular search engine today. Create complex ad campaigns on Google advertising campaigns and have someone manage it for you. Be sure to analyze your competitors and rank web sites before starting your campaign so you know what keywords to invest

Use social media. This means that you will use Facebook, Twitter, YouTube, MySpace, and LinkedIn to promote your business. It is highly recommended to hire a social media marketing consultant to create your marketing strategy for this platform. Hire a team to work on this campaign will be a great idea too. Labor can be cheaper because you can hire a virtual company staff to perform the job. Let your social media consultant to choose the team to work for you.

In addition to online marketing strategies, you can get more traffic to your site on a regular basis to continue to upload new content that is relevant to your niche to article directories online and streaming video sites. You can consider buying ad space on websites that are constantly getting high or hits daily traffic however; this may be an expensive ad.

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