বুধবার, ৩ জুলাই, ২০১৩

Silver Shows Mettle Against Bacteria

60-Second Science

Microbes exposed to a small amount of silver become more vulnerable to antibiotic attack. Karen Hopkin reports.

More 60-Second Science

If you?re plagued by werewolves, reach for the silver. And more mundane health problems may also respond well to the silver solution. Because a new study shows that microbes exposed to a pinch of the precious metal become more vulnerable to antibiotic attack. The research is in the journal Science Translational Medicine. [Jose Ruben Morones-Ramirez et al, Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria]

Silver?s long been a medical treatment. Hippocrates himself applied it to open wounds. But its use as a cure for contagion fell by the wayside with the discovery of penicillin, and the source of its bug-blasting abilities remained a mystery. Until now.

Researchers treated E. coli bacteria with small amounts of silver. They found that the metal messes with the bugs? proteins, wreaking havoc on their metabolism. It also generates reactive chemicals that attack the microbes from within. All this weakens the bacteria?s defenses, which allows other, more conventional antibiotics to slip in and do their work. Even killing microbes that were formerly antibiotic resistant.

Mice with fatal infections were also saved with a silver and antibiotic combo, and at doses that did the sick rodents no harm. This silver was delivered by injection. For werewolves, the preferred silver delivery system is still the bullet.

?Karen Hopkin

[The above text is a transcript of this podcast]?


Source: http://rss.sciam.com/~r/sciam/chemistry/~3/G7LGt6QgqWk/episode.cfm

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মঙ্গলবার, ২ জুলাই, ২০১৩

Fishing in the sea of proteins: Composition of splicing complex in chloroplasts identified for the first time

July 2, 2013 ? To convert a gene into a protein, a cell first crafts a blueprint out of RNA. One of the main players in this process has been identified by researchers led by Dr. Jessica Jacobs at the Ruhr-Universit?t Bochum. The team "fished" a large complex of proteins and RNA, which is involved in the so-called splicing, from the chloroplasts of the green alga Chlamydomonas reinhardtii. This cuts non-coding regions out of the messenger RNA, which contains the protein blueprint.

"For the first time, we have established the exact composition of an unknown splicing complex of the chloroplasts," says Jacobs. She reports with her colleagues from the Department of General and Molecular Botany and the Work Group for Biomolecular Mass Spectrometry in the journal Molecular and Cellular Proteomics.

From gene to protein -- craftwork required

Genes, the bearers of genetic information, contain coding and non-coding regions. To convert a gene into a protein, enzymes first create a copy of the gene, the messenger RNA. A useful blueprint for a protein is only obtained, however, when enzymes cut the non-coding regions, called introns out of the messenger RNA. Scientists call this process splicing. Large complexes of RNA and proteins are responsible for the splicing.

Components of the splicing complex identified in chloroplasts

The RUB researchers examined the splicing of the gene psaA, which is found in chloroplasts. These cellular constituents of plants which carry out photosynthesis probably originated from formerly free-living cyanobacteria. According to the endosymbiotic theory, the cyanobacteria lived in symbiosis with the plants and were eventually integrated into their cells. Chloroplasts therefore have their own genetic material -- a relic from the cyanobacterial genome. However, the chloroplasts are dependent on the communication with the cell nucleus in order to be functional. The Bochum team identified the components of the protein complex that splices the chloroplast gene psaA. In the splicing complex they found 23 different proteins that are encoded in the genome of the cell nucleus. "The protein complex discovered gives us an insight into the functioning of components involved in the communication between chloroplasts and the nucleus," says Jessica Jacobs.

How to fish a splicing complex

The team carried out its investigations on the unicellular green alga Chlamydomonas reinhardtii. "We used a protein bait to fish the splicing complex out of the chloroplasts," says Jacobs. Before starting the experiment, it was known that the protein Raa4 is involved in the splicing of the psaA gene. The many interaction partners of Raa4, however, were unknown. The RUB biologists genetically altered the alga in such a way that it produced a modified form of the protein Raa4 -- with a tag, i.e. a kind of "fish hook." They isolated all the proteins of the cell and filtered them through a particular material, on which only Raa4 got caught on its fish hook -- along with all of its bound interaction partners. They determined the components of the splicing complex fished out with the aid of mass spectrometry. The researchers found a splicing complex with the same composition for various environmental conditions: in light, darkness, and in an oxygen-free environment.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/mKj79pHOV54/130702100109.htm

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Apple files application for 'iWatch' trademark in Japan

Apple files application to register 'iWatch' trademark in Japan

Evidence is mounting that Apple might out a smartwatch in the near future after Yahoo Japan noticed that the company applied for the "iWatch" trademark in Japan on June 3rd. Our Japanese editor noticed that several other companies have applied for that term as well, though this one (released on June 27th) is from Apple Inc. of Cupertino. That follows a patent application from Apple we saw earlier in the year for a watch-like AMOLED device that proposed a slap bracelet, kinetic energy charger and "end-detection" user sensor, among other features. In addition, other rumors from Bloomberg back in February suggested that 100 Apple employees were working on a smartwatch of some kind. If we don't see a device after all that, Cupertino's gone to a heck of a lot of trouble for nothing -- check after the break for a screen grab (in Japanese) of the trademark application.

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Via: Yahoo Japan (translated)

Source: http://www.engadget.com/2013/07/01/apple-files-application-to-register-iwatch-trademark-in-japan/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Analysis: After selloff, some dip toes back in emerging markets

By Gertrude Chavez-Dreyfuss

NEW YORK (Reuters) - The threat of less central bank stimulus and higher interest rates has crushed emerging markets more than most assets in the past two months, in some cases slashing the value of stocks and bonds in developing countries to levels not seen since the last financial crisis.

The slump after U.S. Federal Reserve Chairman Ben Bernanke signaled in May that the Fed expects to curb and then end its bond-buying program in the next year if the economy improves has pushed prices to levels that would have looked very appealing only a few weeks ago. And some emerging market investors are buying, even with the understanding that there is a big risk markets have further to drop.

"We're starting to selectively increase our exposure to emerging markets," said Andres Calderon, portfolio manager and vice president for research at Hansberger Global Investors in Fort Lauderdale, Florida. "But the key word is selective. We're not rushing in."

There is every reason to be cautious: Many fund managers expect lower growth in emerging markets. Some markets have suffered recently from steep capital outflows, and the slowdown in China has affected other emerging economies, particularly commodity producers. Still, emerging markets are expected to continue to grow faster than developed countries.

Northern Trust Asset Management, for one, has remained overweight in emerging market stocks through the slide. The Chicago-based firm manages $810 billion in assets.

"If you're worried about performance in the next one or two quarters, then it's hard to make a case about a visible catalyst for emerging markets," said Jim McDonald, Northern Trust's chief investment strategist. "But if you have a 12- to 18-month outlook, then this group will work."

He said emerging market stocks are trading at around 10 times this year's earnings, or a 32 percent discount relative to the Standard & Poor's 500-stock index. The asset class's historic low is about eight times earnings.

Emerging markets have typically traded at a 20 percent discount to the S&P 500 since 2005.

The price-to-book ratio of emerging market stocks on the MSCI stock index is also showing sharp undervaluation at 1.45, not far from the low of 1.36 hit during the depths of the financial crisis, according to Morgan Stanley data. That is still far higher than the 0.93 reached during the Asian crisis of 1997-98. The price-to-book multiple measures the company's value if it goes bankrupt.

"I wouldn't be surprised, though, if EM stocks come down further because there would still be continued outflows from the sector," said Calderon of Hansberger, which is a long-term investor in emerging market equities, with assets of around $6.2 billion.

There is plenty of wreckage to survey for possible bargains.

The benchmark MSCI emerging market stock index <.mscief> is down about 11.3 percent this year, with much of the decline coming in the past six weeks. By contrast, the MSCI's all-country world equity index <.miwd00000pus> is still up 4.8 percent this year, while the S&P 500 <.spx> sports a sizable 12.8 percent gain for 2013.

In the debt market, the emerging market bond yield spread on dollar-denominated bonds, a gauge of perceived risk over safe-haven U.S. Treasuries, was at 342 basis points on Thursday on the benchmark JP Morgan Emerging Markets USD Bond Index (EMBI+) <.jpmembiplus> . On Tuesday, the spread was its widest in more than a year.

This index has fallen about 6 percent in June and is down more than 10.7 percent this year, after gains of more than 18 percent in 2012.

SLOWER EMERGING MARKET GROWTH

Emerging markets are experiencing a slowdown in demand for exports because of the weakness of the world's major economies. China's downturn has had a severe impact on many developing economies.

"China is likely to be far less effective as an engine for global recovery than in previous episodes such as 2009," said Bhanu Baweja, an investment strategist at UBS in London.

J.P. Morgan, in its June 28 research note, has reduced its growth forecast for emerging markets as a group in 2013 to 4.6 percent from its previous estimate in March of 5.1 percent. The U.S. investment bank has also lowered emerging market growth in 2014 to 5.1 percent from its initial forecast of 5.4 percent.

Still. those growth numbers are way above estimates in developed markets, which are forecast to grow just 1 percent this year and 1.8 percent in 2014, J.P. Morgan data show.

VALUE IN BONDS

Brazilian government bond yields maturing in 2021 have risen by 245 basis points since May, while Mexican bond yields have increased by 144 basis points, according to Morgan Stanley. The firm's latest emerging market bond models suggest those markets are now undervalued.

"The selloff in Mexico is not justified," said Nicolas Jaquier, emerging market debt economist at Standard Life Investments in London, which manages assets of $272.6 billion.

"Growth in Mexico has come down a little bit and it's going through a soft patch, but that is good for bond investors because that means the central bank could cut rates again this year if growth continues to soften."

Standish Asset Management, a $170 billion fixed-income investment firm in Boston, has bought local Mexican and Brazilian bonds as yields have fallen since the May selloff. The average yield on emerging market local bonds is about 6.2 percent, Standish said, or about 100 basis points higher before the selloff in May.

"Many investors are comfortable with the currency volatility attached to these local bonds, and the expectation is that in the medium term, emerging market currencies will appreciate," said Alexander Kozhemiakin, managing director and emerging markets debt team leader at Standish.

Near-term risks in emerging market currencies have declined, since many of the aggressive bets in favor of these assets have been reduced. For instance, net longs - bets a currency will rise - in the Mexican peso, the most liquid emerging market currency, tumbled to around $812 million, the latest data from the Commodity Futures Trading Commission show. That is down sharply from roughly $6 billion in April.

Long positions in the Brazilian real and Chilean peso have also substantially fallen, according to Morgan Stanley data.

There is still a risk of further outflows from the local currency debt sector, fund managers say. Morgan Stanley data shows emerging market institutional investors are still overweight on local debt relative to their benchmark, suggesting more room to pare positions should markets remain scary.

"When you see that exposure indicator going down, that's a sign that the market is starting to clear their positions and therefore there would be a sense of calm," said Rashique Rahman, global head of emerging market strategy at Morgan Stanley in New York.

Analysts at Bank of America/Merrill Lynch said in a Thursday note that institutions they surveyed are raising cash in expectation of outflows, as investors respond to the volatility. Once that is alleviated, the case for long-term bets becomes clearer, fund managers said.

(Editing by David Gaffen, Martin Howell and Douglas Royalty)

Source: http://news.yahoo.com/analysis-selloff-dip-toes-back-emerging-markets-193933467.html

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সোমবার, ১ জুলাই, ২০১৩

Poland's big day: 2 men reach Wimbledon quarters

Poland's Lukasz Kubot celebrates defeating France's Adrian Mannarino during day seven of the All England Lawn Tennis championship at Wimbledon London Monday July 1, 2013. (AP Photo/Dominic Lipinski/PA) UNITED KINGDOM OUT

Poland's Lukasz Kubot celebrates defeating France's Adrian Mannarino during day seven of the All England Lawn Tennis championship at Wimbledon London Monday July 1, 2013. (AP Photo/Dominic Lipinski/PA) UNITED KINGDOM OUT

Jerzy Janowicz of Poland reacts after beating Jurgen Melzer of Austria during their Men's singles match at the All England Lawn Tennis Championships in Wimbledon, London, Monday, July 1, 2013. (AP Photo/Anja Niedringhaus)

Lukasz Kubot of Poland returns to Adrian Mannarino of France during their Men's singles match at the All England Lawn Tennis Championships in Wimbledon, London, Monday, July 1, 2013. (AP Photo/Alastair Grant)

(AP) ? On one of Poland's best days on the tennis court, one of Poland's best players gave a shout-out to none other than ... America's Pete Sampras and Andre Agassi.

Hard to blame Jerzy Janowicz for that.

Truth is, apart from Wojtek Fibak, a wily doubles foe of John McEnroe's who made three Grand Slam singles quarterfinals in 1980, there aren't many luminaries to choose from on the list of Poland's greatest men's tennis stars.

"Yeah, it's unbelievable what's going on right now," Janowicz said after beating Jurgen Melzer 3-6, 7-6 (1), 6-4, 4-6, 6-4 at Wimbledon on Monday to become Poland's first men's Grand Slam quarterfinalist since Fibek.

Janowicz's next opponent: That would be Lukasz Kubot, whose five-set win over Adrian Mannarino ended minutes after Janowicz's victory, thus making him Poland's second men's Grand Slam quarterfinalist in 33 years.

Kubot celebrated by walking to the far end of the service line, then doing his own version of the can-can, high-stepping it across the court before falling into the arms of his coach and friends in the stands.

"My (coaches) told me that every time I'm going to play on the big courts, the big tournaments, big events, I should do the can-can after a win," Kubot said. "So I've had no other chances and I had to do it."

Janowicz, the 22-year-old who said he grew up wanting to be like Sampras and Agassi, will meet Kubot on Wednesday and the winner will become Poland's first men's Grand Slam semifinalist.

Keeping an eye on that one will be Agnieszka Radwanska, also from Poland, who won her own match, 4-6, 6-3, 6-3 over Tsvetana Pironkova of Bulgaria, to move to the quarterfinals and cap a great day for her country.

"They really have nothing to lose," Radwanska said. "For sure that will be very good match."

When Serena Williams lost, fourth-seeded Radwanska became the highest-seeded player left in an upset-strewn women's draw. She was a finalist here last year, so seeing her this far along in the tournament isn't such a surprise.

(Quick stat: Poland has three of the final 16 singles spots at Wimbledon this week. The United States? One: Sloane Stephens.)

The men are a different story.

Though Janowicz vaulted nearly 200 spots in the rankings when he made the finals at the 2012 Paris Masters ? "I gave answer to this question about 58 times,'" he said when asked how that changed his life ? this is only his fifth Grand Slam tournament. At 6-foot-8, he's advancing with the help of a serve that has topped out at 140 mph, the fastest of the tournament so far.

In his win over Melzer, Janowicz was hardly acting like a newbie, bickering with the umpire, at one point complaining after a call on the baseline: "The ball was so out. It's only one line! It's not complicated! One line!"

Afterward, he griped about the condition of Court 12, saying he slipped four times during his 3 hour, 12 minute match.

"I think this Court 12 is unplayable," he said. "Was really bad conditions today."

Kubot's court assignment for his match against Mannarino was even less plum.

They played on Court 14 ? a court near a busy walkway that more fans breeze past than pay attention to. The match all the makings of a typical Monday showdown at the All England Club. The first Monday, that is, not the second.

Couldn't blame the schedulers for that.

Mannarino was ranked 111 and Kubot 130.

Kubot's career record before Monday's match was 90-106 and he hadn't been past the round of 16 in any tournament this year.

But things are changing quickly. After getting a walkover over Steve Darcis, the man who beat Rafael Nadal in the first round, Kubot won in straight sets over 25th-seeded Benoit Paire. He had 26 aces against Mannarino ? 10 more than his big-serving countryman had in his five-setter ? including 11 in the fifth set.

The 31-year-old Kubot said playing doubles, where he's enjoyed more consistent success, has put him on the court with a lot of the best players and prepared him for something like this.

"So I didn't feel surprised," he said of the feelings of being in a big match.

Next up, a meeting with Janowicz, his Davis Cup teammate who, back in 2006, was approached by the Qatari government, asking if he'd play for that oil-rich country.

"I actually said, straightaway, 'No,'" Janowicz said.

Why not? "Because."

Turns out, playing for Poland has served him quite well.

"You should go to Poland and see what's going to happen," Kubot said. "I think that tennis is getting very popular in Poland, and I'm happy and proud we can represent our country in these kinds of tournaments."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-07-01-TEN-Wimbledon-Poland/id-3fea4c57908e4d92a7dee4ed5730ec6d

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The California State Assembly voted to approve a bill this week that would prote...

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10 Things to Know for Today

In this 2012 photo provided by the Cronkite News, Phillip Maldonado, a squad leader with the Granite Mountain Hotshots, trains crew members on setting up emergency fire shelters. On Sunday, June 30, 2013, 19 members of the Prescott, Ariz.-based crew were killed in the deadliest wildfire involving firefighters in the U.S. for at least 30 years. The firefighters were forced to deploy their emergency fire shelters - tent-like structures meant to shield firefighters from flames and heat - when they were caught near the central Arizona town of Yarnell, according to a state forestry spokesman. (AP Photo/Cronkite News, Connor Radnovich)

In this 2012 photo provided by the Cronkite News, Phillip Maldonado, a squad leader with the Granite Mountain Hotshots, trains crew members on setting up emergency fire shelters. On Sunday, June 30, 2013, 19 members of the Prescott, Ariz.-based crew were killed in the deadliest wildfire involving firefighters in the U.S. for at least 30 years. The firefighters were forced to deploy their emergency fire shelters - tent-like structures meant to shield firefighters from flames and heat - when they were caught near the central Arizona town of Yarnell, according to a state forestry spokesman. (AP Photo/Cronkite News, Connor Radnovich)

Opponents of Egypt's Islamist President Mohammed Morsi hold an Egyptian flag as protest outside the presidential palace in Cairo, Egypt, Monday, July 1, 2013. Hundreds of thousands thronged the streets of Cairo and cities around the country Sunday and marched on the presidential palace, filling a broad avenue for blocks, in an attempt to force out the Islamist president with the most massive protests Egypt has seen in 2? years of turmoil. (AP Photo/Hassan Ammar)

Your daily look at late-breaking news, upcoming events and the stories that will be talked about today:

1. 19 IN ELITE FIREFIGHTING UNIT KILLED BATTLING ARIZONA BLAZE

The "hot shot" firefighters were brought into the central Arizona town of Yarnell to protect residents from a fire that destroyed 200 homes.

2. PROTESTERS STORM HEADQUARTERS OF MORSI GROUP

They ransacked the Cairo headquarters of Morsi's Muslim Brotherhood as protesters geared up for a second day of rallies aimed at forcing the president from power.

3. WHO'S LEVELING NEW SURVEILLANCE ACCUSATIONS

Key allies are threatening sanctions against the U.S. over a report of covert listening devices installed in European Union offices.

4. KERRY LEAVES MIDEAST TO MEND FENCES WITH CHINA, RUSSIA

He arrived in Brunei today for a regional security conference, where he is likely to talk to both nations' ministers about NSA leaker Eric Snowden.

5. SAN FRANCISCO TRANSIT WORKERS STRIKE

Two of the area's rapid transit unions are walking out today, derailing more than 400,000 riders who use the nation's fifth-largest rail system.

6. TWO U.S. PRESIDENTS IN AFRICA

Obama finishes his African tour in Dar es Salaam, Tanzania, where former president George W. Bush is attending a conference.

7. DEADLY FALL AT CIRQUE DU SOLEIL

A 31-year-old French performer was being hoisted up the side of the stage when she plummeted to an open pit during the "Ka" show in Las Vegas.

8. RECREATING PIVOTAL CIVIL WAR BATTLE

History buffs playing Union and Confederate soldiers shook hands near a stone wall after re-enacting the 150th anniversary of the Battle of Gettysburg.

9. LOST LIMB RETURNED AFTER MORE THAN 40 YEARS

An American doctor flew into Vietnam to return the bones of an arm he amputated from a soldier in 1966.

10. WILD PERFORMANCES AT BET AWARDS

Erykah Badu brought a white poodle onstage for her act, and Charlie Wilson jammed with Justin Timberlake. No one won the top video of the year award.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-07-01-10%20Things%20to%20Know-Today/id-13fcfc8d4d4e492298d6e2b0e743950e

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