মঙ্গলবার, ২৯ জানুয়ারি, ২০১৩

Clinton says she doesn't see 'getting back into politics'

WASHINGTON (Reuters) - Outgoing U.S. Secretary of State Hillary Clinton on Tuesday cast doubt on speculation she might run for the White House in 2016.

In an interview taped for National Public Radio, Clinton was asked what questions she needs to answer for herself as she decides whether to run for president.

"I'm not even posing those questions. I am really looking forward to stepping off the fast track that I've been on. I've been out of politics as Secretary of State. I don't see myself getting back into politics," she said, according to an excerpt of the interview.

Whether this is her last word on the subject is unknown. She will face strong pressure from Democrats to join the field of contenders. Clinton will step down this week, following Senate confirmation Tuesday of Massachusetts Democratic Senator John Kerry as her successor.

Those close to Clinton are eager for her to announce a 2016 run, so much so that a group has already formed a new super PAC and registered with the Federal Election Commission on Friday, called "Ready for Hillary."

In 2008, she lost to President Barack Obama in a bitter Democratic primary campaign to be the party nominee for the White House.

Although Clinton, 65, did not categorically rule out another presidential run, in a separate NBC interview she said that she was healthy enough to wage a campaign.

"I have no doubt that I am healthy enough and my stamina is great enough and I'll be fully recovered to do whatever I choose to do," Clinton told "Andrea Mitchell Reports" in an interview that aired on Tuesday.

Clinton was hospitalized in December after doctors found a blood clot stemming from a concussion she suffered previously.

She intends to do more public speaking and writing, and work alongside her husband, former President Bill Clinton, and daughter Chelsea on "mutual foundation interests," she said in the NPR interview.

"I want to be involved in philanthropy, advocacy, working on issues - like women and girls - that I care deeply about," Clinton said.

(Reporting by Margaret Chadbourn; Editing by Cynthia Osterman)

Source: http://news.yahoo.com/clinton-says-she-doesnt-see-getting-back-politics-015239548.html

capybara duggars peter facinelli bobby rush supreme court justices 19 kids and counting danny o brien

PFT: Eagles' unlikely to decide on Vick soon

Philadelphia Eagles quarterback Vick throws a pass as he is rushed by New York Giants Umenyiora in the second quarter during their NFL football game in East RutherfordReuters

While it?s true that the Philadelphia Eagles won?t be dumping quarterback Mike Vick before $3 million of his $15.5 million base salary becomes fully guaranteed on February 6, the Eagles won?t be taking their time in deciding whether Vick will be moving along.

The plan, as we understand it, will unfold like a flow chart.

Step one, new Eagles coach Chip Kelly will study film in an effort to decide whether he wants Vick or Nick Foles or someone else to be the team?s quarterback.

Step two, if Kelly decides that he definitely wants Vick, will be to try to work out an alternative arrangement that entails Vick making less than $15.5 million.? The amount the Eagles are willing to pay will be determined in large part by how badly Kelly wants Vick.? There?s a chance, in theory, that Kelly will want Vick badly enough to bite the bullet and pay the full amount.

There?s also a chance Vick will want to play for Kelly badly enough to take a proverbial haircut on his promised pay.

Step three, if it?s determined that Kelly doesn?t want Vick or that Vick won?t accept whatever reduced contract the team is offering, will be to try to trade Vick to another team that would pay him more than the Eagles are willing to pay ? and that would also give the Eagles value in return for the 2010 comeback player of the year.

Time is of the essence on all steps, because if the Eagles are going to maximize trade interest and trade value, they need to do it before teams make other plans at quarterback, by signing for example a free agent.? It?s expected that the Eagles will head to the Scouting Combine with an action plan, with the hopes of getting an agreement in principle with a new team well before March 13, when trades will become finalized.

Complicating a potential trade is that a new team would have to pay Vick $15.5 million this year or persuade him to take less.

If the Eagles can?t trade Vick and if they can?t work out a new deal with him, that?s when things will get interesting.? If Vick shows up for the start of the offseason workout program in April and drops a dumbbell on his foot or pops an Achilles while running at the practice facility, the Eagles will owe him the full amount of his salary if/when he lands on injured reserve.

The Eagles could be tempted to try to block Vick from the facility, like the Titans did several years ago with the late Steve McNair.? But McNair ultimately won his grievance on that issue, and the Eagles would be tiptoeing into dangerous territory if they try to freeze Vick out.

That approach also would counter the team?s new effort to treat its players with a higher level of respect and dignity, an approach that G.M. Howie Roseman seems to be adopting in the wake of the departure of former team president Joe Banner.? (This presumes that there was a problem under Banner; some with the Eagles may be trying to sell the idea that there was.? The Mike Patterson debacle would tend to counter the idea that everything is fine and dandy now.)

Regardless, while the Eagles aren?t worried about next week?s deadline, they?ll be operating on internal deadlines that will prevent this from lingering deep into the offseason.

Source: http://profootballtalk.nbcsports.com/2013/01/29/decision-on-michael-vick-likely-not-coming-soon/related/

Prop 30 Election 2012 Michigan Election Results Missouri Election Results Amendment 64 marijuana huffington post

China May End Decade-Long Ban on Game Consoles - HotHardware

Were you aware that game consoles are banned in China? Due to fears that these devices could harm the physical and mental development of children, seven Chinese ministries decided to ban the manufacture, sale, and import of game consoles a little over a decade ago. Now authorities in Beijing are starting to rethink things.

Citing an anonymous government source, China Daily reports that China is warming to the idea of lifting the ban on game consoles, which would open up a potentially massive market for Microsoft, Sony, and Nintendo to tap into.

"We are reviewing the policy and have conducted some surveys and held discussions with other ministries on the possibility of opening up the game console market," a source from the Ministry of Culture told China Daily. "However, since the ban was issued by seven ministries more than a decade ago, we will need approval from all parties to lift it."


Come console makers already have a presence in China. Sony, for example, has a branch in South China's Guangdong province where it conducts training and research and development, while Microsoft's Kinect motion controller was introduced to the mainland last year. The Kinect isn't used for playing games in China, however, but for medical treatment and educational purposes.

Ironically enough, China is the biggest manufacturing base for Microsoft's Xbox console, even though the market is inaccessible and has a major piracy problem.

Source: http://hothardware.com/News/China-May-End-DecadeLong-Ban-on-Game-Consoles/

projectglass stock act new york auto show khalid sheikh mohammed masters par 3 gwen stefani overeem

All The President's Plans

By MICHAEL FALCONE ( @michaelpfalcone )

NOTABLES:

OBAMA IN VEGAS: President Obama maps out his immigration plan at this afternoon in Las Vegas where, a senior administration official tells ABC's Reena Ninan, he will focus largely on what he's discussed before. The president won't put forward a bill - instead he'll support the Senate's principles outlined yesterday and explain what else needs to be done. The White House feels Las Vegas is a community symbolic of the growing Latino population in both the state and the nation and since immigration reform is a pledge the president made during the campaign, the White House says he wants to deliver.

EL DIABLO IS IN THE DETAILS: Even the senators who wrote the immigration reform proposal outlined yesterday admitted there's lots of work still ahead. One land mine: Some Republicans want to link getting green cards to whether the border is secure. Border security still a gray issue. If the Gang of Eight's efforts fall apart the president's team will step in with its own proposal, Ninan notes.

SECRET CONGRESSIONAL GROUP WORKING ON IMMIGRATION ALTERNATIVE: A separate bipartisan group of lawmakers in the House of Representatives is on the verge of finalizing its own designs for comprehensive immigration reform, ABC's John Parkinson reports. The discussions, which top aides close to the talks discussed on the condition that they not be identified, are described as "Washington's best-kept secret." Multiple sources say those involved in the talks include Democratic Reps. Xavier Becerra (California), Luis Gutierrez (Illinois), Zoe Lofgren (California), and Republican Reps. Mario Diaz-Balart (Florida), Sam Johnson (Texas) and John Carter (Texas). The House's not-yet-finalized proposal is expected to address five general areas of immigration reform, according to aides close to the negotiations. Secure the border, implement a permanent E-verify system nationwide, reform the visa system, address the predicament of how to handle immigrants already in the country illegally in a "fair" and "legal manner" while determining how to handle those who have applied for legal immigration and are currently waiting in line, and reform the immigration system for future applicants. http://abcn.ws/WnjOfh

THE ROUNDTABLE:

ABC's RICK KLEIN: What could possibly go wrong? The bipartisan Senate proposal is on the table, with boldfaced names like McCain, Rubio, Graham, Schumer, Durbin, and Menendez signed on. The House isn't far behind. And the president takes up the mantle himself today, as he lobbies the public to force action at last on immigration reform ? Wait, this could get interesting, after all. The White House has had mixed results with letting Congress handle the details of much of anything. But these are the kinds of details that members of Congress from both parties have spent months if not years wrestling through; witness the twin failures of immigration reform, in 2006 and 2007, under the leadership of a different president. The real question for the White House: Will heavy involvement - and pushing in directions the Gang of Eight doesn't want to go - be more harmful for helpful?

ABC's MICHAEL FALCONE: At yesterday's bi-partisan news conference announcing the Gang of Eight's immigration reform principles, Sen. John McCain's answer about why Republicans were so eager to move on the issue was telling. "Elections, elections," the Arizona senator said. "The Republican Party is losing the support of our Hispanic citizens." He's right: Hispanic voters are becoming a larger share of the electorate and GOP presidential candidate, Mitt Romney, won just 27 percent of the vote among the group compared to 71 percent who supported President Obama. There was also something striking about watching Florida Sen. Marco Rubio, a member of the immigration reform group, launch into Spanish during the press conference. Neither Rubio's language skills nor his familiarity with the immigration issue are breaking news, but I imagine it will give other potential 2016 Republicans pause.

ABC's SHUSHANNAH WALSHE: Currently, the prevailing theory about Sarah Palin is that because she doesn't have the megaphone of Fox News anymore, the "Palin moment" is now officially over. It might be true, but there have been so many "Ends of Sarah Palin" that it's almost hard to keep track. She was over when she lost the 2008 campaign, she was over when she quit the Alaska governorship, she was over when she decided to do a reality show, she was over when she decided not to run for president. Now she's over because she severed her ties with Fox. But the reality is different. Even after she decided to resign as governor and to pass up a 2012 presidential bid, people who both love her and hate her still just couldn't get enough information about her. Palin still got an incredible amount of coverage and her voice was heard - loud and clear. It's yet another example of what she's able to pull off that others who came before or after just aren't: She's been written off since Day One, but she keeps coming back.

ABC's JASON RYAN: The FBI has released new gun background check data yesterday showing that the week after the Newtown massacre (December 14, 2012) was the busiest for gun background checks ever, followed by the week President Obama announced new gun control proposals on January 16, 2013. As ABC News has reported, gun sales have been booming since Newtown. After previously denying journalists access to gun data, National Instant Check System figures show that overall in December 2012 there were more than 2.78 million background checks carried out to purchase firearms surpassing the previous record from November 2012 when more than 2 million checks were performed. The number of total sales during the first month of the new year will be released in the first few days of February.

VIDEO OF THE DAY: MEET DEFIANT DEMOCRAT, HEIDI HEITKAMP. Sen. Heidi Heitkamp, D-N.D., defied the odds in November when she won the closest senate race in the country, and now that she's arrived in Washington, she's defiant as ever. But now, instead of defying the pollsters, she's defying the Democratic caucus by taking divergent opinions on issues central to the President Obama's second term agenda, ranging from gun control to the environment. Heitkamp, who says growing the economy is her top priority, is concerned that the president is changing his focus to issues like climate change and gun control. "I think, you know the one thing that has gotten lost by everyone is one of the best ways that we can perform here is by getting people back to work, making sure that this economic recovery, slow as it is, gets amped up and moves forward," Heitkamp tells ABC's Jonathan Karl, host of "Politics Confidential." "It's one of the reasons why I've been such a big proponent of the Keystone Pipeline. There's a shovel ready, private sector jobs program, good paying jobs." WATCH: http://yhoo.it/TQOxTJ

BUZZ

IMMIGRATION REFORM PLAN INCLUDES A PATHWAY TO CITIZENSHIP. The Senate's plan does not grant undocumented immigrants automatic "amnesty," rather it requires them to go through an arduous process that includes undergoing a background check, paying fines, back taxes and learning English and American civics over the course of a number of years, reports ABC-Univision's Jordan Fabian. The new law would grant eligible undocumented immigrants permission to live and work in the U.S. legally, but would not confer permanent legal status, or a green card, until the border is deemed to be secure. Young people brought into the U.S. illegally as minors and some agricultural workers would face an easier path to citizenship. "We will never put these people on a path to citizenship until we have secured the border," New York Sen. Chuck Schumer said yesterday. Sen. John McCain, R-Ariz., who helped lead the last effort on a comprehensive immigration bill in 2007 said, "We have been too content for too long to allow individuals to mow our lawns, grow our food, clean our homes, and even watch our children while not affording them any of the benefits that make our country so great." http://abcn.ws/YBGY4Q

OBAMA TALKS GUN VIOLENCE WITH POLICE CHIEFS. President Obama is enlisting the help of police chiefs from communities devastated by mass shootings as he continues a public push for Congress to act on his proposals to curb gun violence, ABC's Mary Bruce notes. "No group is more important for us to listen to than our law enforcement officials," the president told reporters before a White House meeting yesterday with sheriffs and police chiefs from across the country. "They are where the rubber hits the road." The president and members of his cabinet met with the police chiefs who responded to the deadly shootings in Aurora, Colo., Oak Creek, Wis., and Newtown, Conn, along with representatives from the Major Cities Chiefs Police Association and the Major County Sheriffs' Association. "I welcome this opportunity to work with them; to hear their views in terms of what will make the biggest difference to prevent something like Newtown or Oak Creek from happening again," Obama said.

CHICK-FIL-A CEO AND GAY ACTIVIST FIND COMMON GROUND. The leader of a national gay-rights group says he's coming out-as a friend of Chick-fil-A CEO Dan Cathy, ABC's Chris Good reports. "I've gotten to know Dan, he's gotten to know me. He's shared concerns about young people, about Chick-fil-A being used for certain purposes," Shane Windmeyer, executive director of Campus Pride, told ABC News. Last year, Cathy sparked a national controversy by telling a radio host that "we're inviting God's judgment on our nation when we shake our fist at him and say we know better than you as to what constitutes a marriage. And I pray God's mercy on our generation that has such a prideful, arrogant attitude that thinks we have the audacity to redefine what marriage is all about." Windmeyer said that Cathy called him last year, during the heat of the controversy that led national gay-rights groups to protest Chick-fil-A. Cathy reached out seeking advice and understanding, Windmeyer said. Windmeyer was a guest of Cathy's at this year's Chick-fil-A Bowl between LSU and Clemson at the Georgia Dome in Atlanta. The activist also says Chick-fil-A has stopped donating to anti-gay groups, according to his review of the company's 990 tax forms. http://abcn.ws/WxuchC

GOVERNMENT WASTE IN THE SPOTLIGHT. The Government Accountability Office is due to produce its biannual report on the areas of the government that present the highest risk for squandering tax payer dollars in the next couple weeks. Though the GAO does not preview this list ahead of time, ABC's Sarah Parnass takes a look at what might be targeted: http://abcn.ws/113uncb

WHO'S TWEETING?

@DavidMDrucker : How central to immigration reform's success is @marcorubio?I'll predict that if he ever backs out bill is dead in House. W/ him: it passes.

@ByronYork: Speaking of deal killers, what will Chairman Leahy do to Gangof8 plan in Sen Judiciary Committee? http://ow.ly/hdUOC

@onetoughnerd: Speaking at @GOVERNING Magazine conference in DC today about how we're reinventing Michigan. http://ow.ly/hdUkP #govlive

@JoshDorner: 4 years ago today, President Obama signed the Lilly Ledbetter Fair Pay Act. It was opposed by all but 8 Congressional Republicans.

@kjplotkin: RT @BobbyJindal: Let's Meet, Mr. President http://www.washingtonpost.com/opinions/bobby-jindal-to-fix-medicaid-listen-to-governors/2013/01/28/ff5c8e5e-6711-11e2-85f5-a8a9228e55e7_story_1.html ?

Also Read

Source: http://news.yahoo.com/presidents-plans-note-142323398--abc-news-politics.html

sacha baron cohen best picture nominees 2012 academy awards 2012 albert nobbs a star is born oscar nominees oscar nominations 2012

IBM links CMS, analytics to Connections - Page 1 - Communications ...

IBM is looking to sign up HR managers to a beefed up version of its enterprise social networking suite Connections which feature new content management and analytics capabilities.

The upgrades on IBM Connections 4.5 include analytic features that enable administrators to monitor such things as collaboration trends among employees as well as customer engagement in social services like Facebook and Twitter.
Image courtesy of ShuterStock.com

?


IBM's latest version of Connections was unveiled today at the Connect 2013 Conference in Orlando brings Connections closers to stronger rivals such as Microsoft?s SharePoint. Connections 4.5 will be available in March this year.

The new content management functions includes features that enable human resources and marketing departments push out to employees collaboration tools for micro blogging, instant messaging, document sharing, video conferencing and content rating. The new tools also manage activity streams, content rating, discussion forums and wikis.

RELATED CONTENT

Some recent surveys, however, suggests that ESN are failing to meet expectations in the large enterprise space.

These surveys show that ESN implementations are weighed down by sharp drop in user interest after an initial surge of fervor. Another common hindrance mentioned is lack of executive buy in.

Essentially, researchers are finding that in many companies there is a dearth of content creators and insufficient interest on the part of intended content consumers.

?

Source: http://www.itworldcanada.com/news/ibm-links-cms-analytics-to-connections/146662

kourtney kardashian pregnant kourtney kardashian pregnant billy cundiff super bowl tickets superbowl birmingham news lee evans

সোমবার, ২৮ জানুয়ারি, ২০১৩

10 Ways to Write Good Copy | Copyblogger

Image of Copyblogger Copywriting 101 Logo

Writing effective copy is both an art and a science.

It?s an art because it requires creativity, a sense of beauty and style ? a certain aptitude, mastery and special knowledge. Artistic advertising allows you to create content marketing that?s not just practical and persuasive, but awe-inspiring and breathtaking.

Writing effective copy is also a science, because it exists in the world of tests, trial and failure, improvement, breakthroughs, education and predictability. Scientific advertising allows you to develop an idea, and then test that idea. It?s how you know if your content marketing is working.

In bad copy, one (or both) of these elements are missing. In good copy, they are both abundant.

Read on, in the next few minutes we?ll explore ten examples of good copy living (and selling) out in the wild ?

1. Plain copy

The most basic approach to writing effective copy is to simply introduce the product without gimmick or style. It?s a simple presentation of the facts and benefits.

There is no story. There is no conversation. There is no ?sizzle? and no superlative claims.

Think Google Analytics.

That copy isn?t going to win any literary awards, but it will get the job done. It will give a prospect the information she needs to make an informed decision about the product.

2. Storytelling copy

Everyone loves a good story.

We like hearing about people ? especially interesting people. People who?ve suffered challenges we can relate to, and can tell us how they overcame those challenges.

And the moral of the story, coincidentally, is that your product was the catalyst to overcoming those odds.

You might find this storytelling technique in an email series, a landing page, or a short video. Whatever the format, you?ll get four basic traits in the story:

  1. Opening: Introduce the pain. Show how the character of the story had a normal life, then how that life was shattered by a change of events.
  2. Conflict: How is the life of the main character threatened if he or she does not respond to the problem? What does her journey look like as she tackles this challenge?
  3. Dialogue: People are drawn to conversations in a story. It?s human interest at its root: two people talking to each other. We are also drawn to dialogue because it?s easy to read. ?Our eyes flow over dialogue like butter on the hood of a hot car,? says novelist Chuck Wendig.
  4. Solution: Finally, your product is introduced as the cure for your character?s problem. You increase the credibility of your product by sharing specific results (347% increase in conversion, for example).

Your story doesn?t have to be dramatic. It just has to be interesting to your target audience. And this is where good research comes in.

3. Conversational copy

John Caples calls conversational copy ?You and Me.?

In this style of copy, you write as if there is a conversation between two people: the copywriter and the prospect.

The language here would be no different than a salesman sitting down for lunch with a customer and talking through a sales presentation. It?s a straightforward approach that tries to identify with the reader:

I know how you feel. I felt the same way. That all changed when I found x, y and z.

Keep in mind that you don?t have to be a polished copywriter to create effective conversational copy. Often the sheer passion for what you?re trying to promote breathes off the page.

In fact, you can record a conversation about the product, transcribe that conversation, and use it as a rough draft.

4. John Lennon copy

When John Lennon asked us to imagine there was no heaven or hell, no countries, religion or war, he was using an effective tool of persuasion: imaginative copy.

As an advertiser, you can ask your target audience to imagine a painless way to lose weight, or what it would feel like to be a successful travel writer.

Imaginative copy typically begins with words like ?imagine,? ?close your eyes,? ?pretend for a moment,? ?discover,? or ?picture this? in the first paragraph of the text.

This is the concept behind AWAI?s Barefoot Writer presentation.

In this example, you are asked to imagine your life in a certain way ? to pretend what it would be like to live your dream, whatever that dream might be.

Then the copywriter paints a picture of achieving that ideal life through your product.

5. Long copy

The fundamental premise behind long copy is ?The more you tell, the more you sell.? Ads that are long on facts and benefits will convert well.

Why?

Unlike a face-to-face conversation with a salesperson, a written ad has only one chance to convert a reader. If you get in front of the reader, you?ve got to lay it all out on the table.

Take the Google Analytics example above.

Page after page of facts and benefits are presented because the proposition isn?t simple ? typical prospects are going to be asking a lot of questions. Better to anticipate those questions, and answer them in the copy.

But when you?re following the basic rules of content marketing that works, remember that you don?t have to present all the facts and benefits up front.

You can leak the presentation over a period of weeks through an email autoresponder (like our Internet Marketing for Smart People course), or a registration-based content library (like the Scribe Content Marketing library).

In this way, you?re turning long copy into short, easily-digestible snippets.

6. Killer poet copy

Here at Copyblogger we love Ernest Hemingway and David Sedaris. But we aren?t so enamored by their writing abilities that we try to imitate their styles at the expense of teaching and selling.

Our goal isn?t to convince our audience that we?re smart ? it?s educating and selling with our copy.

As David Ogilvy once said, ?We sell, or else.? But we try to sell with style. We try to balance the killer with the poet.

Killer poet copy sees writing as a means to an end (making a sale), and the ad as an end in itself (beautiful design and moving story).

In other words, the killer poet combines style with selling. Creativity with marketing. Story with solution.

7. Direct-from-CEO copy

It?s a known fact ? third-party endorsements can help you sell products.

But it?s equally effective to position your selling argument as a direct communication between the company founder and his or her customer.

This down-to-earth approach levels the playing field. It telegraphs to the customer, ?See, the CEO isn?t some cold and remote figurehead interested in profit only. He?s approachable and friendly. He cares about us.?

Jeff Bezos of Amazon is a superb example:

Notice this letter is conversational as well as plain: it?s a simple statement of the facts and benefits between two people: Jeff and you.

8. Frank copy

Some copy will explain the ugly truth about product.

This approach doesn?t start with the jewels of your goods ? it?s going to start with the warts.

When selling a car, you might point out the endless repairs that need to be done ? thin brake pads, leaky transmission, busted sway bar, and inoperable dashboard ? before you introduce the leather seats, Monsoon stereo system, sun roof, brand-new tires and supercharged engine.

What you?re saying is this car will need a lot of TLC. You might even go as far as to say, ?Make no mistake here ? there?s much work to be done here.?

And here?s a curious thing: when you are honest and transparent about product weaknesses, the customer trusts you.

When the reader trusts you, they will be considerably more likely to believe you when you point out the good qualities of your product.

9. Superlative copy

There are also times when you can make outlandish claims.

Claims like (these are actual ads):

  • ?A revolutionary material from this Nevada mine could make investors a fortune in 2013?
  • ?Stores across U.S. selling out of what some call a new ?miracle? diet fighter?
  • ?Obey this one weird loophole to get car insurance as low as $9?

But you can make only make extraordinary claims when you have the proof to back it up. The evidence can be in statistics, testimonials, or research ? or preferably all three.

The problem with superlative copy is that it?s often hard to make outlandish claims and not sound like you are hyping it up ? so use this type of copy sparingly.

Generally, it?s good to follow the ?Remove All Hype? policy.

10. Rejection copy

Rejection copy turns conventional wisdom on its head. and tries to discourage people from being interested in your product.

This type of copy is a direct challenge to the reader that leverages the velvet rope approach ? the idea that only an exclusive set of people are invited to use a product.

The American Express Black Card is a good example here ? this card is reserved for the world?s wealthiest and most elite. The only way you can get your hands on one is if you are invited.

Similarly, consider the dating site Beautiful People. If you want to be part of this exclusive dating club made up of ?beautiful? people, then you have to be voted in by existing members:

Potential rejection startles readers ? they don?t expect to be turned down, especially not from an advertiser.

This approach also keys into our sense of wanting to belong. It generates that curiosity itch and activates our pride. We think, ?How dare they say I might not be good enough to get into their club? I?ll show them.?

Over to you ?

In the end, great copy often combines several of these techniques into one ad.

The CEO of a company writes a conversational sales letter built around a story about his passion for his product (whether it is peaches or water pumps).

A copywriter writes a long rejection ad that explains why certain people are excluded from receiving an invitation to dine at an exclusive restaurant.

Or a Savile Row tailor writes a plain but elegant sales letter about his suits, which have been worn by kings and presidents.

This is the art and science of copywriting.

Can you share any examples of good copy you?ve secently out there in the wild?

Want more? Click here to learn how to write copy that converts.

About the Author: Demian Farnworth is Chief Copywriter for Copyblogger Media. Follow him on Twitter or Google+.

Tweet

Source: http://www.copyblogger.com/good-copywriting/

9/11 Jerry Lawler godaddy andy murray Samsung Galaxy S3 bachelor pad bachelor pad

One-step test for mitochondrial diseases

Jan. 28, 2013 ? More powerful gene-sequencing tools have increasingly been uncovering disease secrets in DNA within the cell nucleus. Now a research team is expanding those rapid next-generation sequencing tests to analyze a separate source of DNA -- within the genes inside mitochondria, cellular power plants that, when abnormal, contribute to complex, multisystem diseases.

The study team, headed by a specialist in mitochondrial medicine at The Children's Hospital of Philadelphia (CHOP), adapted next-generation sequencing to simultaneously analyze the whole exome (all the protein-coding DNA) of nuclear genes and the mitochondrial genome. "A first step in developing treatments for a disease is to understand its precise cause," said Marni J. Falk, M.D., the director and attending physician in the Mitochondrial-Genetic Disease Clinic at Children's Hospital. "We have developed a one-step, off-the-shelf tool that analyzes both nuclear and mitochondrial DNA to help evaluate the genetic cause of suspected mitochondrial disease."

Falk and colleagues describe their customized, comprehensive test, which they call the "1:1000 Mito-Plus Whole-Exome" kit, in the journal Discovery Medicine, published Dec. 26, 2012. Her co-corresponding author, biostatistician Xiaowu Gai, Ph.D., now of the Loyola University Stritch School of Medicine, collaborated on developing the test while at Children's Hospital.

While each mitochondrial disease is very rare in the population, hundreds of causes of mitochondrial diseases are known. Some originate in mutations in DNA specific to the mitochondria, tiny structures located outside the cell nucleus, while many other mitochondrial diseases are based in nuclear DNA genes that affect mitochondrial function. The role of mitochondria in human disease has been recognized only since the 1980s, based on pioneering research by Douglas C. Wallace, Ph.D., now at Children's Hospital, and a co-author of the current study.

Many mitochondrial diseases remain poorly understood. One complicating factor is heteroplasmy -- a mixture of mutated and normal mitochondrial genomes within the same cells or tissues. In contrast to conventional gene sequencing, which can detect only heteroplasmic mutations that reach levels of at least 30 to 50 percent, the customized kit has the sensitivity to detect mitochondrial genome mutations present at levels as low as 8 percent. To achieve their results, the study team adapted an existing whole-exome sequencing kit from Agilent Technologies, expanding it to encompass the mitochondrial genome.

The availability of the new kit, said Falk, if used for either clinical or research purposes, may shorten the "diagnostic odyssey" experienced by many patients and families seeking the cause of debilitating and puzzling symptoms. "Many families travel from one specialist to another for years, searching for the cause of their rare disease," she says. Specific treatments are not always available, but identifying their disease cause may be the first step toward discovering treatments.

A second recent study by Falk and colleagues reviews progress in diagnosing mitochondrial disease, through their experience at a single center over a rapidly changing three-year period before whole-exome sequencing was generally available. The retrospective review in Neurotherapeutics, published Dec. 27, 2012, covers 152 child and adult patients evaluated at CHOP's Mitochondrial-Genetics Diagnostic Clinic from 2008 to 2011.

"Before 2005, very few individuals could receive definitive molecular diagnoses for mitochondrial diseases, because of limitations in both knowledge and technology," said Falk. "Since that time, the clinical ability to sequence whole mitochondrial DNA genomes has significantly improved the diagnosis of many mitochondrial disorders."

During the study period covered in the review article, the clinic at CHOP confirmed definite mitochondrial disease in 16 percent of patients and excluded primary mitochondrial disease in 9 percent. While many diagnostic challenges clearly remain, Falk says the advent of massively parallel nuclear exome sequencing is revealing increasingly more of the genes in nuclear DNA that affect mitochondrial function, and the precise genetic disorder in a given patient, even if it is novel or uncommon. She added that molecular genetics is yielding a more nuanced understanding of the cellular pathways underlying symptoms in many mitochondrial disorders. "Those pathways offer potential new targets for treating these disorders," said Falk.

Funding for both studies came from the National Institutes of Health, grant DK082446. The Discovery Medicine study also was funded through a Foerderer Award for Excellence from The Children's Hospital of Philadelphia Research Institute. Co-authors of the Discovery Medicine study included Eric A. Pierce, M.D., Ph.D., and Mark Consugar, M.S., of the Massachusetts Eye and Ear Infirmary; research and development staff from Agilent under the guidance of Emily LeProust, Ph.D.; and other collaborators from CHOP.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Children's Hospital of Philadelphia, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. Elizabeth McCormick, Emily Place, Marni J. Falk. Molecular Genetic Testing for Mitochondrial Disease: From One Generation to the Next. Neurotherapeutics, 2012; DOI: 10.1007/s13311-012-0174-1
  2. Marni J Falk et al. Mitochondrial Disease Genetic Diagnostics: Optimized Whole-Exome Analysis for All MitoCarta Nuclear Genes and the Mitochondrial Genome. Discovery Medicine, 2013

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/1fk6Vf99Vs4/130128163336.htm

moonrise kingdom coachella lineup joran van der sloot coachella 2012 lineup school delays critics choice awards 2012 honey badger